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MVP showed superiority to EP in another trial (Ginopoulos et al, 1997). A recent trial that compared triple therapy with cisplatin plus ifosfamide plus mitomycin (MIP) with gemcitabine plus cisplatin showed a higher response rate in the double therapy regimen and no difference in survival between the two arms (Crino et al, 1999). Other comparisons between double and triple therapy with modern drugs did not show any advantage for triple therapy over double therapy (Alberola et al, 2001; Souquet et al, 2001)..

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