PAR 1 is one of a family of receptors that is activated by the serine protease thrombin (Coughlin, 1993). Although the best described function of thrombin concerns its role in blood coagulation, it has also been shown to be a powerful agonist that can elicit a variety of cellular responses including mitogenesis (Brass et al., 1998; Van Obberghen Schilling and Pouyss 1993). Additionally, PAR 1 overexpression has been implicated in the invasive properties of various human cancers (Even Ram et al., 1998; Henrikson et al., 1999).
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